研究報告

ライフスタイルと生活習慣病の関連を評価するコホート研究が多いですが、それ以外にもいろいろな研究をやっています。興味がある方は管理人までお知らせ下さい。

2022年度 (Impact Factor 2021, 合計25.611)

合計5報、筆頭著者2報、責任著者3報

  1. 微小変化型ネフローゼ症候群の早期寛解予測因子は高eGFRと低アルブミン血症である:日本ネフローゼ症候群コホート研究JNSCS (IF 4.996)
    Yamamoto R*
    , Imai E, Maruyama S, Yokoyama H, Sugiyama H, Takeda A, Uchida S, Tsukamoto T, Tsuruya K, Akai Y, Nitta K, Fukunaga M, Hayashi H, Masutani K, Wada T, Konta T, Katafuchi R, Nishio S, Goto S, Tamai H, Shirasaki A, Shoji T, Nagai K, Nishino T, Yamagata K, Kazama JJ, Hiromura K, Yasuda H, Mizutani M, Naruse T, Hiramatsu T, Morozumi K, Sobajima H, Saka Y, Ishimura E, Ichikawa D, Shigematsu T, Sofue T, Fujimoto S, Ito T, Sato H, Narita I, Isaka Y. Predictors of early remission of proteinuria in adult patients with minimal change disease: a retrospective cohort study. Sci Rep 2022; 12: 9782.
    https://doi.org/10.1038/s41598-022-13067-7
     
  2. 朝食を食べない阪大生は頻回飲酒になりやすい:後ろ向きコホート研究 (IF 6.706)
    Matsumura Y, Yamamoto R*, Shinzawa M, Matsushita T, Yoshimura R, Otsuki N, Mizui M, Matsui I, Kaimori J, Sakaguchi Y, Ishibashi C, Ide S, Nakanishi K, Nishida M, Kudo T, Yamauchi-Takihara K, Nagatomo I, Moriyama T. Skipping breakfast and incidence of frequent drinking in university students: A retrospective cohort study. Nutrients 2022; 14: 2657.
    https://doi.org/10.3389/fmed.2022.955928
     
  3. 微小変化ネフローゼ症候群における急性腎障害と蛋白尿の寛解:日本ネフローゼ症候群コホート研究 (IF 6.234)
    Yamamoto R*, Imai E, Maruyama S, Yokoyama H, Sugiyama H, Takeda A, Uchida S, Tsukamoto T, Tsuruya K, Akai Y, Nitta K, Fukunaga M, Hayashi H, Shoji T, Masutani K, Konta T, Katafuchi R, Nishio S, Wada T, Goto S, Tamai H, Shirasaki A, Nagai K, Nishino T, Yamagata K, Kazama JJ, Hiromura K, Yasuda H, Sofue T, Fujimoto S, Mizutani M, Naruse T, Hiramatsu T, Morozumi K, Sobajima H, Saka Y, Ishimura E, Ito T, Ichikawa D, Shigematsu T, Sato H, Narita I, Yoshitaka I, on behalf of the Japan Nephrotic Syndrome Cohort Study (JNSCS) investigators, Acute kidney injury and remission of proteinuria in minimal change disease, Kidney Int Rep.
    https://doi.org/10.1016/j.ekir.2022.07.173
     
  4. Soluble ACE2と脂質代謝 (IF 5.058)
    Nagatomo I, Nakanishi K, Yamamoto R, Ide S, Ishibashi C, Moriyama T, Yamauchi-Takihara K. Soluble ACE2 association with lipid metabolism. Front Med. 9: 955928
    https://doi.org/10.3389/fmed.2022.955928
     
  5. 機械学習による一次性ネフローゼ症候群患者の臨床経過分類(IF 2.617)
    Deep learning analysis of clinical course of primary nephrotic syndrome: Japan Nephrotic Syndrome Cohort Study (JNSCS). Cli Exp Nephrol.
    https://doi.org/10.1007/s10157-022-02256-3

2021年度 (Impact Factor 2020, 合計32.262)

合計9報、筆頭著者2報、責任著者5報

  1. 大阪大学職員における平日と週末の睡眠時間差とストレス反応:横断研究 (IF 3.492)
    Adachi H*, Yamamoto R, Fujino R, Kanayama D, Sakagami Y, Akamine S, Marutani N, Yanagida K, Mamiya Y, Koyama M, Shigedo Y, Sugita Y, Mashita M, Nakano N, Watanabe K, Ikeda M, Kudo T. Association of weekday-to-weekend sleep differences and stress response among a Japanese working population: a cross-sectional study. Sleep Med 2021; 82: 159–164. PMID 33933720
     
  2. 一人住まいの阪大生は太りやすい:後ろ向きコホート研究 (IF 3.087)
    Yamamoto R*, Shinzawa M, Yoshimura R, Taneike M, Nakanishi K, Nishida M, Yamauchi-Takihara K, Kudo T, Moriyama T. Living alone and prediction of weight gain and overweight/obesity in university students: a retrospective cohort study. J Am Coll Health Online ahead of print. PMID 34586035
    一人住まいの大学生は太りやすい傾向が明らかに (ResOU)
     
  3. 膜性増殖性腎炎とC3腎症の臨床所見と予後:日本腎生検レジストリ (IF 3.240)
    Nakagawa N*, Mizuno M, Kato S, Maruyama S, Sato H, Nakaya I, Sugiyama H, Fujimoto S, Miura K, Matsumura C, Gotoh Y, Suzuki H, Kuroki A, Yoshino A, Nakatani S, Hiromura K, Yamamoto R, Yokoyama H, Narita I, Isaka Y. Demographic, clinical characteristics and treatment outcomes of immune-complex membranoproliferative glomerulonephritis and C3 glomerulonephritis in Japan: A retrospective analysis of data from the Japan Renal Biopsy Registry. PLoS One 2021; 16: e0257397. PMID 34520493
     
  4. 在宅緩和ケアのがん患者の介護度と家族の時間的負担感:J-HOPE4研究 (IF 3.603)
    Otsuki N, Yamamoto R*, Sakaguchi Y, Masukawa K, Morita T, Kizawa Y, Tsuneto S, Shima Y, Fukui S, Miyashita M: Care needs level in long-term care insurance system and family caregivers’ self-perceived time-dependent burden in patients with home palliative care for cancer: a cross-sectional study. Support Care Cancer 2021; 30: 1587-1596. PMID 34542734
    在宅がん患者の介護者は、時間的要因を最も負担に感じている (ResOU)
     
  5. エビデンスに基づくCKD診療ガイドライン2020ダイジェスト版 (IF 2.801)
    Wada T, Ishimoto T, Nakaya I, Kawaguchi T, Sofue T, Shimizu S, Kurita N, Sasaki S, Nishiwaki H, Koizumi M, Saito S, Nishibori N, Oe Y, Yoshida M, Miyaoka Y, Akiyama S, Itano Y, Okazaki M, Ozeki T, Ichikawa D, Oguchi H, Kohsaka S, Kosaka S, Kataoka Y, Shima H, Shirai S, Sugiyama K, Suzuki T, Son D, Tanaka T, Nango E, Niihata K, Nishijima Y, Nozu K, Hasegawa M, Miyata R, Yazawa M, Yamamoto Y, Yamamoto R, Shibagaki Y, Furuichi K, Okada H*, Narita I: A digest of the Evidence-Based Clinical Practice Guideline for Nephrotic Syndrome 2020. Clin Exp Nephrol 2021; 25: 1277–1285. PMID 34564793
     
  6. 野菜嫌いの阪大職員は蛋白尿の発症リスクが高い:後ろ向きコホート研究 (IF 3.374)
    Ozaki S, Yamamoto R*, Shinzawa M, Tomi R, Yoshimura R, Nakanishi K, Nishida M, Nagatomo I, Kudo T, Yamauchi-Takihara K, Isaka Y, Moriyama T. Vegetable Preference and Prediction of Proteinuria: A Retrospective Cohort Study. Ann Nutr Metab 2021;77:337-43. PMID 34700317
    「野菜は好きですか?」でわかる腎臓病のリスク (ResOU)
     
  7. 医療機関での腎臓検査歴も健診受診歴も無い寝屋川市民は末期腎不全の発症リスクが高い:NHHKコホート研究 (IF 4.379)
    Yoshimura R, Yamamoto R*, Shinzawa M, Kataoka R, Ahn M, Ikeguchi N, Wakida N, Toki H, Moriyama T. Associations of kidney tests at medical facilities and health checkups with incidence of end-stage kidney disease: a retrospective cohort study. Sci Rep 2021; 11: 20717. PMID 34702949
    健診や医療機関で腎臓の検査を受けていない 高齢男性は透析のリスクが高いことが明らかに (ResOU)
     
  8. 阪大職員のライフスタイルとFGF21:横断研究 (IF 4.379)
    Nakanishi K, Ishibashi C, Ide S, Yamamoto R, Nishida M, Nagatomo I, Moriyama T, Yamauchi-Takihara K: Serum FGF21 levels are altered by various factors including lifestyle behaviors in male subjects. Sci Rep 2021; 11: 22632. PMID 34799626
    抗肥満因子の血中濃度は 生活習慣により変化することが明らかに (ResOU)
     
  9. 微小変化型ネフローゼ症候群における寛解までの期間と再発率:日本ネフローゼ症候群コホート研究JNSCS (IF 3.902)
    Yamamoto R*, Imai E, Maruyama S, Yokoyama H, Sugiyama H, Takeda A, Tsukamoto T, Uchida S, Tsuruya K, Shoji T, Hayashi H, Akai Y, Fukunaga M, Konta T, Nishio S, Goto S, Tamai H, Nagai K, Katafuchi R, Masutani K, Wada T, Nishino T, Shirasaki A, Sobajima H, Nitta K, Yamagata K, Kazama JJ, Hiromura K, Yasuda H, Mizutani M, Akahori T, Naruse T, Hiramatsu T, Morozumi K, Mimura T, Saka Y, Ishimura E, Hasegawa H, Ichikawa D, Shigematsu T, Sato H, Narita I, Isaka Y; Japan Nephrotic Syndrome Cohort Study investigators. Time to remission of proteinuria and incidence of relapse in patients with steroid-sensitive minimal change disease and focal segmental glomerulosclerosis: the Japan Nephrotic Syndrome Cohort Study. J Nephrol 2022; 35: 1135-1144. PMID 35366214

2020年度 (Impact Factor 2019, 合計33.925)

合計11報、筆頭著者3報、責任著者5報

  1. 飲酒頻度が高い塩野義製薬社員は、塩分摂取が多いほど尿アルブミンが出やすい:コホート研究 (IF 2.941)
    Yoshimura R, Yamamoto R*, Shinzawa M, Tomi R, Ozaki S, Fujii Y, Ito T, Tanabe K, Moriguchi Y, Isaka Y, Moriyama T. Frequency of alcohol drinking modifies the association between salt intake and albuminuria: a 1-year observational study. Hypertens Res 2020; 43: 1249-1256. PMID 32175653
     
  2. 高齢者膜性腎症の寛解率:日本ネフローゼ症候群コホート研究JNSCS (IF 1.770)
    Yokoyama H*, Yamamoto R, Imai E, Maruyama S, Sugiyama H, Nitta K, Tsukamoto T, Uchida S, Takeda A, Sato T, Wada T, Hayashi H, Akai Y, Fukunaga M, Tsuruya K, Masutani K, Konta T, Shoji T, Hiramatsu T, Goto S, Tamai H, Nishio S, Shirasaki A, Nagai K, Yamagata K, Hasegawa H, Yasuda H, Ichida S, Naruse T, Fukami K, Nishino T, Sobajima H, Tanaka S, Akahori T, Ito T, Terada Y, Katafuchi R, Fujimoto S, Okada H, Ishimura E, Kazama JJ, Hiromura K, Mimura T, Suzuki S, Saka Y, Sofue T, Suzuki Y, Shibagaki Y, Kitagawa K, Morozumi K, Fujita Y, Mizutani M, Shigematsu T, Furuichi K, Fujimoto K, Kashihara N, Sato H, Matsuo S, Narita I, Isaka Y. Better remission rates in elderly Japanese patients with primary membranous nephropathy in nationwide real-world practice: The Japan Nephrotic Syndrome Cohort Study (JNSCS). Clin Exp Nephrol 2020; 24: 893-909. PMID 32562107
     
  3. IgA腎症に対するステロイドの腎保護効果:後ろ向きコホート研究STOP-IgAN (IF 1.770)
    Nagasawa Y*, Yamamoto R, Shinzawa M, Shoji T, Hasuike Y, Nagatoya K, Yamauchi A, Hayashi T, Kuragano T, Moriyama T, Isaka Y. Efficacy of corticosteroid therapy for IgA nephropathy patients stratified by kidney function and proteinuria. Clin Exp Nephrol 2020; 24: 927-934. PMID 32642919
     
  4. デスクワークの阪大職員は蛋白尿のリスクが高い:後ろ向きコホート研究 (IF 3.484)
    Fujii Y, Yamamoto R*, Shinzawa M, Kimura Y, Aoki K, Tomi R, Ozaki S, Yoshimura R, Taneike M, Nakanishi K, Nishida M, Yamauchi-Takihara K, Kudo T, Isaka Y, Moriyama T. Occupational sedentary behavior and prediction of proteinuria in young to middle‑aged adults: a retrospective cohort study. J Nephrol 2021; 34: 719-728. PMID 32852701
    デスクワークの男性は蛋白尿のリスクが高い可能性が明らかに (ResOU)
     
  5. 慢性腎臓病患者に対する運動療法の有効性:システマティックレビュー (IF 3.484)
    Yamamoto R*, Ito T, Nagasawa Y, Matsui K, Egawa M, Nanami M, Isaka Y, Okada H. Efficacy of aerobic exercise on the cardiometabolic and renal outcomes in patients with chronic kidney disease: a systematic review of randomized controlled trials. J Nephrol 2021; 34: 155-164. PMID 33387341
     
  6. 朝食夕食を抜く阪大女性職員は蛋白尿のリスクが高い:後ろ向きコホート研究 (IF 4.546)
    Tomi R, Yamamoto R*, Shinzawa M, Kimura Y, Fujii Y, Aoki K, Ozaki S, Yoshimura R, Taneike M, Nakanishi K, Nishida M, Yamauchi-Takihara K, Kudo T, Isaka Y, Moriyama T. Frequency of Breakfast, Lunch, and Dinner and Incidence of Proteinuria: A Retrospective Cohort Study. Nutrients 2020; 12: 3549. PMID 33228218
    朝食・夕食を食べない女性は蛋白尿のリスクが高いことが明らかに (ResOU)
     
  7. 大阪府国保加入者の特定健診ビッグデータを利用したDirectLiNGAM法による因果推論:横断研究 (IF 2.740)
    Kotoku J*, Oyama A, Kitazumi K, Toki H, Haga A, Yamamoto R, Shinzawa M, Yamakawa M, Fukui S, Yamamoto K, Moriyama T. Causal relations of health indices inferred statistically using the DirectLiNGAM algorithm from big data of Osaka prefecture health checkups. PLoS One 2020; 15: e0243229. PMID 33362207
     
  8. 阪大職員の血清Klothoレベルは高血糖と関連している:横断研究 (IF 1.927)
    Nakanishi K, Nishida M, Taneike M, Yamamoto R, Moriyama T, Yamauchi-Takihara K*. Klotho Levels Contribute to the Prevention of Disease Progression. Int J Gen Med 2021; 14: 229-236. PMID 33519229
     
  9. α-Klothoは心不全患者における治療反応性の予測因子である (IF 3.998)
    Taneike M, Nishida M, Nakanishi K, Sera F, Kioka H, Yamamoto R, Ohtani T, Hikoso S, Moriyama T, Sakata Y, Yamauchi-Takihara*. Alpha-Klotho is a novel predictor of treatment responsiveness in patients with heart failure. Sci Rep 2021; 11: 2058. PMID 33479413
     
  10. 阪大生おける朝食、昼食、夕食の欠食頻度と肥満:後ろ向きコホート研究 (IF 4.546)
    Yamamoto R*, Tomi R, Shinzawa M, Yoshimura R, Ozaki S, Nakanishi K, Ide S, Nagatomo I, Nishida M, Yamauchi-Takihara K, Kudo T, Moriyama T. Associations of Skipping Breakfast, Lunch, and Dinner with Weight Gain and Overweight/Obesity in University Students: A Retrospective Cohort Study. Nutrients 2021; 13: 271. PMID 33477859
    肥満リスクに新知見!朝食のほかに夕食の摂取頻度にも注意 (ResOU)
     
  11. 一次性ネフローゼ症候群におけるレニン-アンギオテンシン系阻害薬の処方関連因子:日本ネフローゼ症候群コホート研究JNSCS (IF 2.719)
    Nishiwaki H*, Niihata K, Shimizu S, Shibagaki Y, Yamamoto R, Nitta K, Tsukamoto T, Uchida S, Takeda A, Okada H, Narita I, Isaka Y, Kurita N, Imai E, Maruyama S, Sato T, Sato H, Wada T, Hayashi H, Akai Y, Fukunaga M, Tsuruya K, Masutani K, Konta T, Yokoyama H, Shoji T, Hiramatsu T, Goto S, Sugiyama H, Tamai H, Nishio S, Shirasaki A, Nagai K, Yamagata K, Hasegawa H, Yasuda H, Ichida S, Naruse T, Fukami K, Nishino T, Sobajima H, Tanaka S, Akahori T, Ito T, Terada Y, Katafuchi R, Fujimoto S, Ishimura E, Kazama JJ, Hiromura K, Mimura T, Suzuki S, Saka Y, Sofue T, Suzuki Y, Kitagawa K, Morozumi K, Fujita Y, Mizutani M, Shigematsu T, Kashihara N, Matsuo S. Incidence and factors associated with prescribing renin‐angiotensin‐system inhibitors in adult idiopathic nephrotic syndrome: A nationwide cohort study. J Clin Hypertens 2021; 23: 999–1007. PMID 33645883

2019年度 (Impact Factor 2018, 合計11.597)

合計5報、筆頭著者1報、責任著者4報

  1. α-Klothoは阪大職員のストレス指標である (IF 1.994)
    Nakanishi K, Nishida M, Taneike M, Yamamoto R, Adachi H, Moriyama T, Yamauchi-Takihara K. Implication of alpha-Klotho as the predictive factor of stress. J Invest Med 2019; 67: 1082-1086. PMID 31324693
    ストレスが老化関連分子の血中濃度を変化させることを発見 (ResOU)
     
  2. 阪大職員における睡眠負債と蛋白尿の有病率:横断研究 (IF 1.971)
    Aoki K, Yamamoto R*, Shinzawa M, Kimura Y, Adachi H, Fujii Y, Tomi R, Nakanishi K, Taneike M, Nishida M, Kudo T, Yamauchi-Takihara K, Isaka Y, Moriyama T. Sleep debt and prevalence of proteinuria in subjects with short sleep duration on weekdays: a cross-sectional study. Clin Exp Nephrol 2020; 24: 143–150. PMID 31691047
     
  3. 飲酒頻度は非肥満の阪大職員高血圧のリスクである:後ろ向きコホート研究 (IF 3.217)
    Nishigaki D, Yamamoto R*, Shinzawa M, Kimura Y, Fujii Y, Aoki K, Tomi R, Ozaki S, Yoshimura R, Taneike M, Nakanishi K, Nishida M, Yamauchi-Takihara K, Isaka Y, Moriyama T. Body mass index modifies the association between frequency of alcohol consumption and incidence of hypertension in men but not in women: a retrospective cohort study. Hypertens Res 2020; 43: 322-330. PMID 31913352
     
  4. 一次性ネフローゼ症候群の寛解、再発、末期腎不全、死亡等のアウトカム発症率:日本ネフローゼ症候群コホート研究JNSCS (IF 1.971)
    Yamamoto R*
    , Imai E, Maruyama S, Yokoyama H, Sugiyama H, Nitta K, Tsukamoto T, Uchida S, Takeda A, Sato T, Wada T, Hayashi H, Akai Y, Fukunaga M, Tsuruya K, Masutani K, Konta T, Shoji T, Hiramatsu T, Goto S, Tamai H, Nishio S, Shirasaki A, Nagai K, Yamagata K, Hasegawa H, Yasuda H, Ichida S, Naruse T, Nishino T, Sobajima H, Tanaka S, Akahori T, Ito T, Terada Y, Katafuchi R, Fujimoto S, Okada H, Ishimura E, Kazama JJ, Hiromura K, Mimura T, Suzuki S, Saka Y, Sofue T, Suzuki Y, Shibagaki Y, Kitagawa K, Morozumi K, Fujita Y, Mizutani M, Shigematsu T, Kashihara N, Sato H, Matsuo S, Narita I, Isaka Y. Incidence of remission and relapse of proteinuria, end-stage kidney disease, mortality, and major outcomes in primary nephrotic syndrome: the Japan Nephrotic Syndrome Cohort Study (JNSCS). Clin Exp Nephrol 2020; 24: 526-540. PMID 32146646
     
  5. 飲酒頻度が高い塩野義製薬社員は塩分摂取が多いほど血圧が上昇しやすい:コホート研究 (IF 2.444)
    Yoshimura R, Yamamoto R*, Shinzawa M, Tomi R, Ozaki S, Fujii Y, Ito T, Tanabe K, Moriguchi Y, Isaka Y, Moriyama T. Drinking frequency modifies an association between salt intake and blood pressure: A cohort study. J Clin Hypertens 2020; 22: 649-655. PMID 32175653