MOOSE (Meta-analysis of Observational Studies in Epidemiology)は、観察研究のシステマティックレビュー論文において記載すべき内容を示したガイドラインです。
Background should include
- Problem definition
明らかにされていない問題点は? - Hypothesis statement
仮説は? - Description of study outcome(s)
アウトカムは? - Type of exposure or intervention used
暴露因子は? - Type of study designs used
研究デザインは? - Study population
研究対象は?
Search strategy should include
- Qualifications of searchers (eg, librarians and investigators)
検索担当者は? - Search strategy, including time period included in the synthesis and keywords
キーワードや期間等の検索式は? - Effort to include all available studies, including contact with authors
著者への連絡は? - Databases and registries searched
検索したデータベースは? - Search software used, name and version, including special features used (eg, explosion)
利用した検索アプリは? - Use of hand searching (eg, reference lists of obtained articles)
ハンドサーチは? - List of citations located and those excluded, including justification
- Method of addressing articles published in languages other than English
英語以外の論文は? - Method of handling abstracts and unpublished studies
学会抄録や未発表データは? - Description of any contact with authors
著者への連絡は?
Methods should include
- Description of relevance or appropriateness of studies assembled for assessing the hypothesis to be tested
研究テーマに見合った論文? - Rationale for the selection and coding of data (eg, sound clinical principles or convenience)
- Documentation of how data were classified and coded (eg, multiple raters, blinding, and interrater reliability)
データの抽出法は? - Assessment of confounding (eg, comparability of cases and controls in studies where appropriate)
交絡の調整方法は? - Assessment of study quality, including blinding of quality assessors; stratification or regression on possible predictors of study results
研究の質の評価方法は? - Assessment of heterogeneity
異質性の評価方法は? - Description of statistical methods (eg, complete description of fixed or random effects models, justification of whether the chosen models account for predictors of study results, dose-response models, or cumulative meta-analysis) in sufficient detail to be replicated
統計手法は? - Provision of appropriate tables and graphics
図表は適切?
Results should include
- Graphic summarizing individual study estimates and overall estimate フォレストプロットは?
- Table giving descriptive information for each study included それぞれの研究の特徴は?
- Results of sensitivity testing (eg, subgroup analysis) 感度分析は?
- Indication of statistical uncertainty of findings 結果の明らかでない点は?
Discussion should include
- Quantitative assessment of bias (eg, publication bias)
出版バイアスは? - Justification for exclusion (eg, exclusion of non–English-language citations)
除外された研究によるバイアスは? - Assessment of quality of included studies
包含された研究の質は?
Conclusions should include
- Consideration of alternative explanations for observed results
異なる視点から研究結果を解釈すれば? - Generalization of the conclusions (ie, appropriate for the data presented and within the domain of the literature review)
外的妥当性は? - Guidelines for future research
- Disclosure of funding source